| abstract |
A compound of formula (I), wherein Y1 and Y2 are each either hydrogen or a hydroxy-protecting group, and wherein the rest of the subtituents are disclosed in the specification. Also claimed are several intermediates from the synthesis method outlined. Also disclosed is the suitability of the above compound for treating a metabolic bone disease, such as senile osteoporosis, postmenopausal osteoporosis, steroid-induced osteoporosis, low bone turnover osteoporosis, osteomalacia, renal osteodystrophy, or for treating psoriasis, leukemiam colon cancer, breast cancer, skin cancer, prostate cancer, or increasing bone strength, either in cortical strength or trabecular strength, or for treating an autoimmune disease such as multiple sclerosis, diabetes mellitus, or lupus, or for treating an inflammatory bowel disease such as Crohn's disease or ulcerative colitis. |