| abstract |
Biological-based polyurethanes and methods of making the same are disclosed. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant. Particularly disclosed is a biodegradable polyurethane composite, comprising: a polyurethane matrix formed by reaction of a polyisocyanate with a biological material to form a biodegradable polyurethane polymer, wherein the biological material is selected from an optionally hydroxylated biomolecule, a small molecule, a bioactive agent, bone, demineralized bone, mineralized bone, modified forms of the above, or combinations of any of the above. The optionally hydroxylated biomolecule may be selected from the group consisting of phospholipids, fatty acids, cholesterols, polysaccharides, starches, and combinations and modified forms thereof. |