http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-541373-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5053f82a7cd17c60822674b657cfb89e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 |
| filingDate | 2004-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f44b88f795e587053ca53040cb30f49f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e13f5514fa42ebfb804c3bcc5c58a4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97f8d9b71b4e8ff014827e798f281e3d |
| publicationDate | 2008-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-541373-A |
| titleOfInvention | Pharmaceutical process for preparing sulfinyl compounds by oxidation of sulfide compounds that are useful as proton pump inhibitors |
| abstract | The present disclosure relates to a process for preparing a sulfinyl compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof. The process comprises oxidation of a sulfide compound of formula (II) wherein in both formulae (I) and (II) R1 and R3 are selected from the group consisting of hydrogen, methyl or C1-4 alkoxy, R2 is selected from the group consisting of substituted or unsubstituted C1-4 alkoxy and R4 is selected from the group consisting of hydrogen or substituted or unsubstituted C1-4alkoxy; wherein an oxidising agent comprising an aqueous alkali or alkali earth metal hypohalite solution, having a concentration in the range of 2 to 5%, is added to a suspension or solution of a sulfide compound of formula (II) to form a reaction mixture, wherein a solution of an alkali or alkali earth metal hydroxide is present in the reaction mixture at least during the oxidation step, whereby the pH of the reaction mixture at least during said oxidation step is in the range of from 9 to 12, and optionally converting a sulfinyl compound of formula (I) to a pharmaceutically acceptable salt, hydrate or solvate thereof. |
| priorityDate | 2003-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.