abstract |
Enantiomerically pure (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide, pharmaceutically acceptable metabolites, polymorphs, salts, solvates, and clathrates thereof are disclosed. Methods of treating and/or preventing various diseases and disorders, such as those ameliorated by the reduction of levels of TNF-alpha or the inhibition of PDE4, are also described. |