| abstract |
Disclosed is a compound of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, wherein 'A' represents a substituted or unsubstituted, group selected from heteroaryl; heterocyclyl groups; 'n' is an integer from 1-3; 'X' represent oxygen; 'Ar' represents a substituted or unsubstituted single or fused divalent phenyl; G1 represents OR1, SR1, S(O)R3, S(O)2R3, N3 CN, COOH, tetrazolyl groups; G2 represents OR1, NR1R2, SR1, S(O)R3, S(O)2R3, N3, CN, COOH, tetrazolyl groups; R1 and R2 represent hydrogen, substituted or unsubstituted groups selected from linear or branched (C1C8)alkyl, acyl, alkoxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl groups; R3 represents substituted or unsubstituted groups selected for alkyl, aryl groups; with the proviso that, when G2 represents NR1R2, G1 does not represent -OH group; and G3 represents hydrogen or (C1-C8)alkyl groups. Also disclosed is the use of the above compound for the preparation of a medicine suitable for the treatment of disease selected from obesity, hyperlipidaemia, hypercholesteremia, hypertension, atherosclerosis, diabetes. |