| abstract |
Disclosed is a compound of formula (I), wherein R represents unsubstituted or substituted lower alkyl, unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted lower alkylamino or a saturated five or six membered heterocyclic group containing one or two nitrogen atoms. The compounds are prodrugs of the alpha2 adrenergic agonist MPV-2426 or [4-(6-hydroxyindan-1-ylmethyl)-1H-imidazol-1-ium chloride, and are useful in the treatment of hypertension, glaucoma, migraine, diarrhea, ischemia, addiction to chemical substances, hypotension, shock, cardiopulmonary resuscitation, micturition disorders, withdrawal syndromes, congestive heart failure, anxiety or different neurological, musculoskeletal, psychiatric or cognition disorders or as a sedative or an analgesic agent, nasal decongestant or as an adjunct to anaesthesia. |