abstract |
Disclosed is a compound having formula I wherein: Z is N; Y is CONR5, NR5CO, SO2NR5, NR5CH2, NR5CONR5, C1-6alkylene, CH2CO, COCH2, CH=CH, OCH2 or CH2O; X is CH or N; P is phenyl or a 6 membered heteroaromatic ring containing one or more heteroatoms independently selected from N, O or S and said phenyl ring or heteroaromatic ring may optionally be fused with a 5 or 6 membered saturated, partially saturated or unsaturated ring containing one or more atoms selected from C, N, O or S; Q is phenyl or a 5 or 6 membered heteroaromatic ring containing one or more nitrogen atoms and said phenyl ring or heteroaromatic ring may optionally be fused with a 5 or 6 membered saturated, partially saturated or unsaturated ring containing one or more atoms selected from C, N, O or S; R is C1-6alkylNR1-R11 or C1-6alkylazetidine which azetidine ring may be optionally substituted by A; and the remainder of the substituents are as described in the specification. Also disclosed is the use of the above compound in the manufacture of a medicament for the prevention and/or treatment of diseases or disorders of the nervous system or for hyperglycaemia or for contraception or for baldness. |