| abstract |
Disclosed are compounds of formula (I) wherein: R1 is alkyl, alkyoxy, thioalkoxy, trifluoroalkyl, trifluoroalkoxy or hydroxyl alkyl; R2 is selected from a substituted or unsubstituted phenyl, thiazole, thiadiazole, pyridine, naphthalene, or a hydroxyalkyl, or NHCOR6 wherein R6 is substituted or unsubstituted aryl; R3 is phenyl, substituted phenyl, aryl, unsubstituted or substituted heteroaryl; one of R4 and R5 is H and the other -(CH2)nR7 wherein R7 is as defined and n=1-3; R8 is phenyl which is unsubstituted or substituted as defined; m=0-2; and X=-NCH3, CH2, S, SO, or SO2. Compounds of the type disclosed are useful in the treatment of mycobacterial infections in mammals. |