| abstract |
Disclosed are protected compounds of formula (III) and (IV) wherein: R1 is -(CH2)-phenyl optionally substituted by one, two, three or four substituents as defined; R2 and R3 are hydrogen; X1 is -Cl, -Br, -I, or -OSO2Rx, where Rx is 4-methylphenyl-, 3-nitrophenyl, or CH3-; and The protecting group is as defined. Compounds of the type disclosed are useful as intermediates in the manufacture of a medicament for treating Alzheimer's disease, in particular for inhibiting beta-secretase-mediated cleavage of amyloid precursor protein (APP). |