abstract |
Disclosed are compounds of formula (Ia), wherein: R1 is CO2R4, R2 is independently -halo, -CN, -OH, -N(R5)(R5), -OR5, -C(O)R5, -OC(O)R5, -C(O)NHC(O)R5, -alkyl, -alkenyl, alkynyl, -cycloalkyl, -bicylcoalkyl, -cycloalkenyl, -heterocycle, -phenyl, -naphthyl, -bicloalkyl, cycloalkenyl, -heterocycle, -phenyl, -naphthyl, -benzyl, -CO2R5, -C(O)OCH(R5)(R5), -NHC(O)R5, -NHC(O)NHR5, -C(O)NHR5, -OC(O)R5, -OC(O)OR5, -SR5, -S(O)R5 or -S(O)2R5, R3 is -H, -halo, -NO2, -CN, -OH, -N(R5)(R5), -O(CH2)mR5, -C(O)R5, -C(O)NR5R5, -C(O)NH(CH2)m(R5), -OCF3, -benzyl, -CO2CH(R5)(R5), -alkyl, -alkenyl, -alkynyl, -cycloalkyl, -bicycloalkyl, -cycloalkenyl, -naphthyl, heterocycle, -CO2(CH2)mR5, -NHC(O)R5, -N(R5)C(O)R5, -NHC(O)NHR5, -OC(O)(CH2)mCHR5R5, -CO2(CH2)mCHR5R5, -OC(O)OR5, -SR5, -S(O)R5, -S(O)2R5, -S(O)2NHR5, or optionally substituted phenyl. The compounds are used for the manufacture of medicaments for the treatment of inflammation diseases in animals. |