| abstract |
A compound of formula I is described to be used in the preparation of a medicament for use in the treatment of a condition mediated by PLK, or susceptible neoplasm, in an animal. R1 is selected from the group consisting of H, alkyl, alkenyl, alkynyl, -C(O)R7, -CO2R7, - C(O)N(R7)R8, -C(O)N(R7)OR8, -C(O)N(R7)-Ph, -C(O)N(R7)-R2-Ph, -C(O)N(R7)C(O)R8, -C(O)N(R7)CO-2R8, -C(O)N(R7)C(O)NR7R8, -C(O)N(R7)S(O)2R8, -R2-OR7, -R2-O-C(O)R7, -C(S)R7, -C(S)NR7R8, -C(S)N(R7)-Ph, -C(S)N(R7)-R2-Ph, -R2-SR7, -C(=NR7)NR7R8, -C(=NR7)N(R8)-Ph, -C(=NR7)N(R8)-R2-Ph, - R2-NR7R8, -CN, -OR7, -S(O)fR7, -S(O)2NR7R8, -S(O)2N(R7)-Ph, -S(O)2N(R7)-R2-Ph, -NR7R8, -N(R7)-Ph, -N(R7)-R2-Ph, -N(R7)-SO2R8 and Het; Q1 is a group of formula: -(R2)a-(Y1)b-(R2)c-R3; n is 0, 1, 2, 3 or 4; Q2 is a group of formula: -(R2)aa-(Y1)bb-(R2)cc-R4, or two adjacent Q2 groups are selected from the group consisting of alkyl, alkenyl, -OR7, -S(O)fR7 and ûNR7R8 and together with the carbon atoms to which they are bound, they form a C5-6cycloalkenyl, phenyl, 5-7 membered heterocycle having 1 or 2 heteroatoms selected from N, O and S, or 5-6 membered heteroaryl having 1 or 2 heteroatoms selected from N, O and S; R5 is selected from the group consisting of H, halo, alkyl, cycloalkyl, OR7, -S(O)fR7, -NR7R8, -NHC(O)R7, -NHC(O)NR7R8 and ûNHS(O)2R7. Also disclosed is the process for preparing a compound of formula I. This comprises reacting a compound of formula III with a compound of formula IV. |