http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-538085-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_26a0119a2d008c6f2a4e634d85bf7b4f |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-714 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-714 |
filingDate | 1999-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_814a6b702e3e2a173705de9fe798ac47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44e0e8d9297a939f953ae0f90c1586bb |
publicationDate | 2006-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | NZ-538085-A |
titleOfInvention | Vitamin B12 derivatives and methods for their preparation |
abstract | Disclosed is a method for preparing vitamin B12 (VB12) derivatives suitable for linking to a polymer, nanoparticle or therapeutic agent, protein or peptide comprising the steps of reacting the 5' OH group of VB12 or an analogue thereof with a bifunctional carbonyl electrophile to form an active intermediate, and subsequently reacting the intermediate with a nucleophilie spacer molecule to yield said VB12 derivative, wherein the bifunctional carbonyl electrophile is selected from the group consisting of carbonyldiimidazole phosgene, triphosgene, N,N disuccinimidyl carbonate, carbonyl dipiperidine, 1,1'-carbonyldi(1,2,4-triazole), di(2-pyridyi)ketone or di(1- benzotriazolyl)carbonate. Also disclosed are specific 5' OH modified derivatives of VB12. |
priorityDate | 1998-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 173.