http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-537561-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f1144e66b5feb529e22d400c1e870f87 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 2003-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9851021a643a06bf6a811eac675f8457 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86f61943ba511e510d211f8c0f391df8 |
| publicationDate | 2008-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-537561-A |
| titleOfInvention | Method for inducing a conformational transition in proteins such as pathogenic/infectious proteins |
| abstract | Disclosed is an in vitro method for increasing the content of beta-sheet secondary structure in recombinant amyloidogenic proteins, comprising: a) mixing a conversion buffer, a solution of lamellar lipid structures that comprise negatively charged lipids and recombinant amyloidogenic proteins; b) exposing the mixture of step a) to a converstion temperature for a time sufficient to increase the beta-sheet secondary structure in the recombinant amyloidogenic proteins, wherein water soluble complexes of lamellar lipid structures and amyloidogenic oligomeric beta-sheet intermediate structures are formed. Also disclosed are amyloidogenic oligomeric beta-sheet intermediate structures produced by the above method. |
| priorityDate | 2002-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.