| abstract |
Disclosed herein are 3-(4-oxo-4H-chromen-2-yl)-(1H)-quinoline-4-one compounds of formula (I), optical isomers, if any, hydrates, solvates, addition salts and pharmaceutically acceptable acids thereof, wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be same or different, each represent a group selected among hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR' wherein R' represents an ionized or ionizable group; R5 represents a group selected among alkyl, aryl and heteroaryl; R7 represents a group selected among hydrogen, hydroxy, alkoxy, alkyl and cycloalkyl, or R7 represents a nitrogenous or oxygen-containing heterocycle. These compounds are suitable for use in an anti-cancer medicament for treating cancer. |