http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-536970-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1542e8802a0e6a7a8a7c6bd5627eb857 |
| filingDate | 2003-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ade80c81f25a2c0d1af114bdee9656b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a8a2c23044858e6344c336817efcd0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_965684c31546d680971ab59c020e2421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a4edd2eb644a80813bca25471985c2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73db28de782210deb10afa4da7d0b390 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5207bbdb3b5e7acf8fec5ee295cb542 |
| publicationDate | 2006-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-536970-A |
| titleOfInvention | Substituted thiophenes, method for the production thereof, their use as a medicament or diagnostic reagent, and a medicament containing the same |
| abstract | Disclosed are compounds of formula I wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification. Compounds of the type disclosed inhibit the cellular sodium/proton exchanger (NHE) and in particular NHE3. They are therefore useful for the treatment of diseases caused by an activation of NHE or by an activated NHE. Disclosed is the use of the compounds for the treatment or prophylaxis of: respiratory disorders, snoring, acute and chronic renal diseases, disorders of intestinal function, high blood pressure, disorders of the CNS, acute and chronic damage and disorders of organs or tissue caused by ischemic events or by reperfusion events and indirect sequelae thereof, arrhythmias, atherosclerosis, hypercholesterolemia, diseases in which cell proliferation is a primary or secondary cause, cancer, prostate hypertrophy or prostate hyperplasia, fibrotic disorders of internal organs, cardiac insufficiency, thromboses, disorder of gall function, infection by ectoparasites, disorders the result of endothelial dysfunction, intermittent claudication, protozoa disorders, states of shock, diabetes and late diabetic damage, acute or chronic inflammatory disorders, the preservation and storage of transplants, for use in surgical operations and organ transplantations, for preventing age related tissue change, maintaining health and prolonging life, for reducing cytotoxic effects or for use as diagnostics. |
| priorityDate | 2002-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 423.