| abstract |
Disclosed is a fused imidazole derivative of formula (I) wherein: T1 represents and optionally substituted monocyclic or bicyclic 4-12 membered heterocyclic group, containing one or two N atoms in the ring; X represents an optionally substituted group selected from alkyl, alkenyl, alkynyl, aryl, heteroaryl, aryl-alkyl, and heteroaryl-alkyl; Z1 and Z2 each independently represent an N atom or a group represented by the formula -CR2=; R1 and R2 each independently represent a group according to the formula -A0-A1-A2- as defined in the specification; and when Z2 is -CR2=, R1, and R2 may in combination form a 5-7 membered ring. Compounds of the type disclosed are dipeptidyl peptidate-IV (DPPIV) inhibitors useful in the treatment of a wide variety of diseases. |