| abstract |
Disclosed are compounds of formula I, wherein: X is N or CH, R1 is cycloalkyl, aryl, heterocycle, aralkyl, heterocycle-alkyl, an oxy derivative, or a bridged carbocycle, R2 is -NR4R5, -OR4 or -C(=O)NR5R6, R3 is tetrazole, -CN, -CH2OH or -CO-R7, and the remaining substituents are defined herein. The compounds are used in the manufacture of medicaments for the treatment of VLA-4 dependent diseases. |