| abstract |
Disclosed is a process for preparing a compound of formula (Vie): wherein R1 is, at each position, independently represented by hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, methoxy, thiomethoxy, -NHA, -NA2, -NHC(=O)A, amino carbonyl, -C(=O)NHA, -C(=O)NA2, halogen, hydroxy, -OA, cyano or aryl; A is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, or optionally substituted alkynyl; R2 is represented by formulae (i), (ii), (iii), or (iv); R" is C1-C4 alkyl; and X is represented by O, S, N or NH; or a pharmaceutically acceptable salt of said compound, comprising reacting a compound of formula (VId), wherein R1, X and R" are defined above, with HR2 in the presence of a catalyst and a base. |