abstract |
Disclosed is a compound of formula (I) wherein the substituents are as described in the specification. Compounds of the type disclosed are NK1 antagonists and are useful for treating a physiological disorder, symptom or disease in a patient in need of such treatment, wherein said physiological disorder, symptom or disease is a respiratory disease, depression, anxiety, phobia, bipolar disorder, alcohol dependence, psychoactive substance abuse, nociception, psychosis, schizophrenia, stress related disorder, obsessive/compulsive disorder, bulemia, anorexia nervosa, binge eating, sleep disorder, mania, premenstrual syndrome, gastrointestinal disorder, obesity, headache, neuropathic pain, post-operative pain, chronic pain syndrome, bladder disorder, genitourinary disorder, cough, emesis or nausea. |