http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-534990-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2003-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fb352b1d14977a57ef48a05141fa379 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6380a621eeb31e882a9f78badc450a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e11e968556decec6cf00903934a155d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a81a7f9459d838bac79c3b9c5e977fe5 |
| publicationDate | 2006-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-534990-A |
| titleOfInvention | Heterocyclic amide derivatives as inhibitors of glycogen phosphorylase |
| abstract | Heterocyclic amide derivatives of formula 1 having glycogen phosphorylase inhibitory activity are described wherein: --- is a single or double bond; X is N or CH; R4 and R5 together are either -S-C(R6)=C(R7)- or -C(R7)=C(R6)-S-; R6 and R7 are independently selected from hydrogen, halo, nitro, cyano, hydroxy, fluoromethyl, difluoromethyl, trifluoromethyl, trifluoromethoxy, carboxy, carbamoyl, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy and C1-4alkanoyl; A is phenylene or heteroarylene; n is 0, 1 or 2; R1 is independently selected from halo, nitro, cyano, hydroxy, carboxy, carbamoyl, N-C1-4alkylcarbamoyl, N,N-(C1-4alkyl)2carbamoyl, sulphamoyl, N-C1-4alkylsulphamoyl, N,N-(C1-4alkyl)2sulphamoyl, -S(O)bC1-4alkyl (wherein b is 0, 1, or 2), C1-4alkyl, C2-4alkenyl, C2- 4alkynyl, C1-4alkoxy, C1-4alkanoyl, C1-4alkanoyloxy, hydroxyC1-4alkyl, fluoromethyl, difluoromethyl, trifluoromethyl and trifluoromethoxy ; or when n is 2, the two R1 groups, together with the carbon atoms of A to which they are attached, may form a 4 to 7 membered ring, optionally containing 1 or 2 heteroatoms independently selected from O, S and N, and optionally being substituted by one or two methyl groups; R2 is hydrogen, hydroxy or carboxy; R3 is selected from hydrogen, hydroxy, C1-4alkoxy, C1-4alkanoyl, carbamoyl, C3-7cycloalkyl (optionally substituted with 1 or 2 hydroxy groups), cyano(C1-4)alkyl, aryl, heterocyclyl, C1- 4alkyl (optionally substituted), and groups of the formulae B and B' wherein y is 0 or 1, t is 0, 1,2 or 3 and u is 1 or 2; provided that the hydroxy group is not a substituent on the ring carbon adjacent to the ring oxygen; with the proviso that the compound of formula (1) is not: (i) 2,3-dichloro-5-[N-2-oxo-1,2,3,4-tetrahydroquinol-3-yl)carbamoyl]-4H-thieno[3,4-b]pyrrole; (ii) 2-chloro-5-[N-(2-oxo-1,2,3,4-tetrahydroquinol-3-yl)carbamoyl]-6H-thieno[2,3- b]pyrrole; (iii) 2-chloro-5-[N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinol-3-yl)carbamoyl]-6H- thieno [2, 3-b]pyrrole. Pharmaceutical compositions comprising the compounds are useful for treating type 2 diabetes, insulin resistance, syndrome X, hyperinsulinaemia, hyperglucagonaemia, cardiac ischemia and obesity |
| priorityDate | 2002-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 451.