| abstract |
A compound of the general formula (I) is described. The radical R1 is a hydrogen atom, a C2-C6 alkenyl or a C1-C6 alkyl radical and may optionally be substituted. The radicals R2, R3, R4 and R5 are each independently of one another a hydrogen atom, a halogen atom, the group -COOH, -CONH2, -CF3, -OCF3, -NO2, -CN, a C1-C6 alkyl, a C2-C6 alkenyl, a C1-C6 alkoxy, a C1-C12 aralkyl, an aryl or hetaryl radical. The radical R6 is the group -CONR8R9, -COOR8, -CH2NR8R9, -CH2R8, -CH2OR8, or a C2-C12 alkenyl radical which is optionally substituted by the radicals R8 and R9. The radical R7 is a C1-C12 alkyl, a C2-C12 alkenyl, a C1-C12 aralkyl, an aryl or hetaryl radical, the group -NR12R13, -NHCOR14, -NHCONHR14, -NHCOOR14 or -NHSO2R14 and may be optionally substituted. The radicals Ra, Rb, Rc, Rd, Re and Rf are each independently of one another a hydrogen atom, a halogen atom, the group -COOH, -CONH2, -CF3, -OCF3, -NO2, -CN, a C1-C6 alkyl, C1-C6 alkoxy, an aryl or hetaryl radical. A proviso explains that the compound of the general formula (I) is not selected from the group consisting of 3-amino-1,2,3,4-tetrahydrocarbazole-3-carboxylic acid, 3-amino-6-methoxy-1,2,3,4-tetrahydrocarbazole-3-carboxylic acid, 3-amino-6-benzyloxy-1,2,3,4-tetrahydrocarbazole-3-carboxylic acid, 3-acetamido-1,2,3,4-tetrahydrocarbazole-3- carboxylic acid, methyl 3-acetamido-1,2,3,4-tetrahydrocarbazole-3-carboxylate, (-) -menthyl 3- acetamido-1,2,3,4-tetrahydrocarbazole-3-carboxylate or 3-tert-butoxycarbonylamino-1,2,3, 4-tetrahydrocarbazole-3-carboxylic acid. The compound is disclosed to be used in a pharmaceutical for the treatment of pathological states mediated by G protein-coupled receptors, such as for male fertility control, treatment of female subfertility or infertility, and female contraception. |