| abstract |
Preventives or remedies for Alzheimer's disease or amyloid protein fibrosis inhibitors are disclosed, which contain, as the active ingredient, at least one nitrogen-containing heteroaryl compound having the general formula (I) or pharmacologically acceptable salts thereof, wherein R1 and R2 represent each H or alkyl; Z1 and Z2 represent each H, alkyl, alkoxy, haloalkyl or halogeno; Z3 represents alkoxy, SH, alkylthio, NH2, mono- or dialkylamino, OH or halogeno; Z4 and Z5 represent each H or halogeno; and A represents 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc. |