| abstract |
Disclosed are compounds of structure Ia or Ib, wherein: Q and Q' are independently H, -CH2-, -O-, -S-, alkyl or substituted alkyl, R1 is H, alkyl or together with Q may be a cycloalkyl ring, R2 may be absent or -CH2-, -CO-, -CH2CH2-, -CH2CO-, -CH2O-, -CRR'-, or -CONR-, Y is H or -OR3 or links A to A' as a single bond, =N- or -NR-, A is -NRR', -OR, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, aryl, substituted aryl, heterocycle or substituted heterocycle, A' is -NRR', and X and X' are independently R, halo, -CO2R, -CN, -NRR', -NRCOR', -NO2, -N3 or -OR. The compounds are used for the manufacture of medicaments for the treatment of conditions wherein the subject suffers from a hypoglutamatergic condition or deficiencies in the number or strength of excitatory synapses or in the number of AMPA receptors such that a cortical/striatal imbalance occurs leading to schizophrenia or schizophreniform behaviour. |