| abstract |
Disclosed is a compound of formula (I); wherein Y is N, C or CH; X is S; m is 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; q is 0, 1, 2, 3 or 4; s is I or 2; the dotted line represents an optional bond; each R1 is independently selected from the group consisting C1-6-alkyl, or two R1 attached to the same carbon atom may form a 3-6-membered spiro-attached cyclo-alkyl; each R2 is independently selected from the group consisting of C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl, hydroxy, hydroxy-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, acyl, C1-6-alk(en/yn)yloxycarbonyl, C1-6-alk(en/yn)ylsulfonyl, -NRxRy, and -NRxCO-C1-6-alk(en/yn)yl; each R3 is independently selected from the group consisting of C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl, hydroxy, hydroxy-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)ylsulfonyl, aryl, C1-6-alk(en/yn)yloxycarbonyl, acyl, -NRxRy, CONRxRy, and -NRxCO-C1-6-alk(en/yn)yl; or two adjacent R3 substituents together form a heterocycle fused to the phenyl ring selected from the group consisting of formula (II) to (VI). Further disclosed are pharmaceutical compositions comprising a compound of formula (I), and the use of compounds of formula (I) in the preparation of a medicament for the treatment of affective disorders, anxiety disorders or an obsessive compulsive disorder. |