| abstract |
An angiotensin peptide moiety-carrier conjugate comprises: (a) a carrier with at least one first attachment site and (b) at least one angiotensin peptide moiety with at least one second attachment site. The carrier comprises a core particle that is a virus-like particle and the second attachment site is capable of association through at least one covalent bond to the first attachment site to form an ordered and repetitive angiotensin peptide moiety-carrier conjugate. Pharmaceutical and vaccine composition comprising the conjugate are described. The compositions are useful for treating disorders associated with rennin-activated angiotensin system such as hypertension, stroke, infarction, congestive heart failure, kidney failure and retinal hemorrhage. |