abstract |
Non-inflammatory vector compositions suitable for repeated transgene delivery and that result in persistent transgene expression are disclosed. The compositions are non-inflammatory, the present compositions are suitable for readministration and do not induce expression-limiting immune or inflammatory responses. Thus, these compositions are useful in methods of repeated administration to achieve persistent transgene expression, and are especially suited to treating genetic, acquired and inflammation-associated conditions. Particularly disclosed is a non-inflammatory vector composition, comprising (i) aqueous free nucleic acid that encodes a gene product and (ii) an anti-inflammatory compound selected from a steroid anti-inflammatory agent and a non- steroid anti-inflammatory agent (NSAID). (62) Divided out of 519756 |