| abstract |
A heterocyclic compound of formula (I) and a pharmaceutically acceptable salt thereof is disclosed, wherein: R1 represents hydrogen or C1"6 alkyl; R2 represents hydrogen, -CO-C(R4)=C(R4)-R5; wherein R4 is hydrogen or C1-4 alkyl and R5 is C4-8 alkyl, C2-8 alkenyl, etc; Y represents a group of formula (II), wherein X is oxygen or sulfur; R7 has the same meaning as R4; R8 is R10-C(R9)=C(R9)- wherein R9 has the same meaning as R4 and R10 is C3-6 alkyl, etc; R14 has the same meaning as R4; and R15 represents aryl, etc; Y-(CH2)n-O- is bonded to the 6- or 7- positon carbon atom of the tetrahydroisoquinoline skeleton; and n is an integer of 1 to 4. The compound of formula (I) is useful as an antihyperglycemic agent, antihyperlipemic agent, insulin resistance improver, diabetes remedy, remedy for complications of diabetes, glucose intolerance improver, antiarteriosclerotic agent, antiobestic agent, anti"inflammatory agent, preventive/remedy for diseases attributable to PPAR, and preventive/remedy for X syndrome. |