| abstract |
Disclosed is a composition comprising modafinil; one or more diluents, each independently chosen from a starch, a lactose monohydrate or a microcrystalline cellulose; one or more disintegrants, each independently chosen from a pregelatinized starch or a cross-linked sodium carboxymethyl cellulose; a binder; and a lubricant; wherein modafinil comprises from about 30-50% by weight of the composition; a diluent is a lactose monohydrate, a second diluent is a microcrystalline cellulose; a disintegrant is a pregelatinized starch, a second disintegrant is a cross-linked sodium carboxymethyl cellulose; the binder is a polyvinyl pyrrolidone, and the lubricant is magnesium stearate; provided the composition does not include magnesium silicate or talc. Further disclosed is the use of the composition in the manufacture of a medicament for the treatment of sleepiness, Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, ADHD, fatigue, cognitive dysfunction and for the promotion of wakefulness. |