http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-529924-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6042ebb427d782607bc67695e232e9d4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0368 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-103 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43531 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 |
| filingDate | 2002-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c4c7d3b72c4be41b70be29064b4216a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9ccb458685dff8e97d76a2dd584ab30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1337ca69b17ed9171e6bcf5f557bb861 |
| publicationDate | 2005-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-529924-A |
| titleOfInvention | In vivo model system for an allergic condition that has been subjected to allergic sensitisation with an antigen that is not a helminth parasite |
| abstract | Described are model systems for allergic conditions, and in particular to in vivo model systems in a large animal. The model systems described are especially useful for providing large numbers of activated or non-activated eosinophils, for the discovery and evaluation of anti-inflammatory drug targets and for providing a model for the in vivo study of asthma and the effects of allergy treatments. In a preferred embodiment the animal is a sheep. In one embodiment, repeated infusion of house dust mite allergen (HDM) into the mammary gland is used to induce a specific allergic response, which is characterised by the recruitment of inflammatory cells, particularly eosinophils, into the mammary lumen; these cells can be harvested from peripheral blood and mammary lavage (MAL). In a second embodiment, the mammal is immunised with soluble antigen, for example by repeated subcutaneous immunisation, and then subjected to a single challenge with the same antigen administered directly to the lung. |
| priorityDate | 2001-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 320.