abstract |
Disclosed are compounds of formula (I), wherein: X is CR4R4' and Y is NR6, Z is O, R1 is alkyl, cycloalkyl, aryl, arylalkyl, alkylaryl, heterocycle, OR2, SR2 or NR2R3, R7 and R8 are both ethoxy. The compounds are used for the manufacture of medicaments for inhibiting a cyclic nucleotide phosphodiesterase, such as for the treatment of neuroinflammation. |