abstract |
A pharmaceutical composition comprising a low-solubility drug adsorbed onto a high surface area substrate to form an adsorbate is disclosed, wherein the pharmaceutical composition comprises a solid adsorbate comprising a low-solubility drug adsorbed onto a substrate to form an adsorbate, the substrate having a surface area of at least 20 m2/g, wherein at least a major portion of the drug in the adsorbate is amorphous; wherein the adsorbate provides improved concentration of the drug in a use environment relative to a slow-evaporation control composition comprising the drug and the substrate but formed by evaporation of solvent from a suspension of the drug in a solvent with the substrate suspended therein, the evaporation of the solvent for formation of the slow-evaporation control composition being conducted over a period of at least 30 minutes. Optionally, these compositions may also include a concentration-enhancing polymer. |