| abstract |
Disclosed are compounds of formula (I), wherein: R1 is H, halogen, nitro, cyano, or -G1-R1a, R2, R3 and R4 are independently H, halogen, cyano, nitro, hydroxyl, aryl, heteroaryl, or -G2-R2a, R2 and R3 or R3 and R4 may together form a 5- to 7-membered ring optionally containing heteroatoms, R5 and R6 are independently -X5-X6-X7, R5 and R6 may together form a 5- to 10-membered ring optionally containing hetero atoms or and carbonyl, R6 and R2 may together form a 6- to 7-membered ring optionally containing hetero atoms and carbonyl, Ar is optionally substituted aryl or heteroaryl. The compounds are used in the manufacture of medicaments as a Corticotropin-Releasing Factor (CRF) receptor antagonists. |