| abstract |
Guanidine and amidine derivative compounds of the formula (I) that exhibit a strong antithrombotic effect are disclosed, wherein R0; Q; X; Q', D, R10 and V have the meanings as described in the specification. These compounds of the formula (I) are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa(FXa) and/or factor VIIa(FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. Processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them are also disclosed. |