| abstract |
Disclosed are compounds of formula (I) and pharmaceutically acceptable salts, solvates, and hydrolysable esters thereof wherein: X1 and X2 are O or S; n is 1-3; One of Y and Z is N, and the other is O; R1 and R2 are independently halogen, H, CH3, OCH3 or C1-3 alkyl; Each R3 independently is halogen CF3, C1-6 straight or branched alkyl; R4 and R5 are independently H or C1-3 alkyl; y is 0-5 Further disclosed are: The use of the compounds of formula (I) in the manufacture of a medicament for the treatment of a hPPAR mediated disease or condition, such as dyslipidemia, syndrome X and heart failure; and Pharmaceutical compositions comprising compounds of formula (I). |