http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-526188-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3720264832de0d78e07da14db302bb5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2001-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45742d61186ca0708197f41446948cd5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74a73a8e588571f96da8f5008d76d6aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4305fd02d67d02d1a49b6cd22e402156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12fd9c6e24d798ba91773f6f580671bd |
| publicationDate | 2004-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-526188-A |
| titleOfInvention | A process for the preparation of iopamidol and the new intermediates therein |
| abstract | A process for the preparation of (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide of formula (I) (iopamidol) starting from 5-amino-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide (II) is disclosed, wherein the process comprises a) reacting the compound of formula (II) with a suitable protecting agent, to give a compound of formula (III) wherein R is a group of formula A or B wherein R1 is a hydrogen atom, a C1-C4 straight or branched alkoxy group, R2 is hydrogen, a C1-C4 straight or branched alkoxy group and R3 is a C1-C4 straight or branched alkyl group, a trifuoromethyl or a trichloromethyl group; b) acylating the amino group in position 5 of the intermediate compound of formula (III), by reaction with a (S)-2-(acetyloxy)propanoyl chloride to give a compound of formula (IV) wherein R is as defined above; and c) removing all the acyl groups present in the compound of formula (IV) under basic conditions, with prior cleavage of the cyclic protections of the hydroxy groups in the carboxamido substituents under acidic conditions, when R is a group of formula A carboxamido hydroxy groups under acidic conditions. The formulae referred herein are as shown in the specification. |
| priorityDate | 2000-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.