| abstract |
An isolated nucleic acid representing a synthetic BAX-gene comprises a nucleic acid sequence as indicated by SEQ ID NO:1. Also described are vectors, isolated host cells comprising the nucleic acid and methods of using the nucleic acid and polypeptides encoded by it for identifying Bax-resistant yeast or fungi, for identifying inhibitors of Bax-induced cell death and for identifying Candida spp. sequences involved in a pathway leading to programmed cell death. |