| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10e4b1416c6e66e0ade5429212414964 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-227
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| filingDate |
2001-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2d49c64d1421d218136e4862c540d2a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acc60f530a5440ed7d8c07ddaf0d42ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1623d66e14496dd76a2d90c7a6f11bf |
| publicationDate |
2004-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-524363-A |
| titleOfInvention |
Processes for preparing cilostazol (6-[4-(1-cyclohexyl- 1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone) |
| abstract |
Processes for preparing 6-[4-(1-cyclohexyl-1H-tetrazol- 5-yl)butoxy]-3,4-dihydro-2(1H-quinolinone of formula (I) which is also known by the generic name cilostazol are disclosed, wherein a process for preparing cilostazol of formula (I) comprises: (a) dissolving 6-hydroxy-3,4-dihydroquinolinone and a water- soluble base in water to form an aqueous phase, (b) dissolving a 1-cyclohexyl-5-(4-halobutyl)-tetrazole in a water-immiscible solvent to form an organic phase, (c) forming a biphasic mixture by contacting the aqueous phase and the organic phase in the presence of a quaternary ammonium phase transfer catalyst, (d) and recovering cilostazol from the biphasic mixture. Cilostazol inhibits cell platelet aggregation and is used to treat patients with intermittent claudication. |
| priorityDate |
2000-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |