| abstract |
A process for the preparation of nucleoside analogues, in particular, the preparation of compounds of general formula (I) is disclosed. The process includes the reaction of formaldehyde, or a formaldehyde equivalent, with a cyclic amine and a heteroaromatic compound to give methylene linked cyclic amine deazapurines. The compounds disclosed are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5'-methylthioadenosine phosphorylases (MTAP), 5'-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH). |