| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_634d7355c2673489b2f4f800541770bb |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 |
| filingDate |
2001-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_382753db6d53ba4d971ac067ff9db85f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd479c7a9e3f253864843527ce804105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cb9857690590b77da17a93d12bf06a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3963dd9b8ad46c3713d67f95612faa04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d75092ca3c57ff7e328c8e1c7f1b254
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c8da4ca83d142556137d3a47edcf77a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e37d9538aa85707675e07c78f9c5c5b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e48e8204ac650af28b42aa71ee593bb0 |
| publicationDate |
2004-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-523803-A |
| titleOfInvention |
Human urocortin-related polypeptide (URP) and uses thereof to rreat a pathophysiological state, eg stress, anxiety and appetite dysfunction |
| abstract |
A human urocortin-related peptide (URP) with significant sequence homology to the corticotrophin releasing factor (CRF) neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituitary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn II. Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1. Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3311830-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2814513-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2013221615-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10202618-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10918738-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013123094-A2 |
| priorityDate |
2000-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |