| abstract |
Peptides derived from heliomicine by substitution of one or several amino acids are described. They are characterised in that the peptides correspond to formula (I) wherein: X1, X17, X21 X43 are amino acids; X16, X44 are small polar amino acids; X19 is a large polar amino acid; X36 is a small or lightly hydrophobic amino acid; X38 is a lightly hydrophobic or small amino acid. The substitutions being such that: at least one of X1, X17, X21and X43 is a basic or polar, advantageously large polar amino acid, and/or at least one of the amino acids X16, X44 is a basic amino acid or a large polar amino acid, and/or X19 is a basic amino acid, and/or at least one of the amino acids X36, X38 is a strongly hydrophobic amino acid. Also described are anti-fungal and/or antibacterial compositions comprising at least one of the aforementioned peptides. |