http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-522960-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4dac022280ec96f54c694eb427655932 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-18 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C275-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4409 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4465 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C273-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-357 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426 |
| filingDate | 2001-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0d6ea0a4cddfe39872b72f0070687b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b4925f0338a338f3945f1bed711f60b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9533e6f2de83d5197569b0882ace7006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7c3230e95edea1299a7acfc05a1ed4b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53cc171612afc26d27b7c88180821d50 |
| publicationDate | 2004-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-522960-A |
| titleOfInvention | Factor VIIA inhibitory (thio)urea derivatives, their preparation and their use |
| abstract | The present invention relates to compounds of the formula I, in which: R1 is selected from hydrogen, hydroxy, (C1-C12)-alkoxycarbonyl-, (C6-C14)-aryl-(C1-C4)-alkoxycarbonyl- and (C6-C14)-aryloxycarbonyl-, where each of the aryl groups is unsubstituted or substituted by one or more identical or different substituents selected from (C1-C12)-alkyl, halogen and (C1-C12)-alkoxy; R2 is selected from hydrogen, (C1-C12)-alkyl, (C6-C14)-aryl, (C6-C14)-aryl-(C1-C4)-alkyl-, R20-( C1-C12)-alkyl-, R20-( C6-C14)-aryl- and R20-( C6-C14)-aryl-(C1-C4)-alkyl-, where R20is selected from hydroxycarbonyl-, (C1-C12)-alkoxycarbonyl- and (C6-C14)-aryl-(C1-C4)-alkoxycarbonyl-; R3 is selected from hydrogen, cyano, hydroxy and (C1-C12)-alkyl; R4 is selected from (C1-C12)-alkyl, (C6-C14)-aryl, (C6-C14)-aryl-(C1-C4)-alkyl-, Het and Het-(C1-C4)-alkyl-, where the alkyl, aryl and Het groups are unsubstituted or substituted by one or more identical or different substituents R10; R5, is selected from hydrogen, (C1-C12)-alkyl, (C6-C14)-aryl, (C6-C14)-aryl-(C1-C4)-alkyl-, Het, Het-(C1-C4)-alkyl-, (C6-C14)-aryl-(C1-C4)-alkyl-aminocarbonyl- and Het-(C1-C4)-alkyl-aminocarbonyl-, where the alkyl, aryl and Het groups are unsubstituted or substituted by one or more identical or different substituents R10; or R4 and R5 together with the carbon atom to which they are bonded form a saturated or unsaturated 3-membered to 8-membered ring which is a carbocyclic ring or a heterocyclic ring containing 1, 2 or 3 identical or different ring heteroatoms selected from nitrogen, oxygen and sulfur, and which can be condensed to one or two saturated or unsaturated carbocyclic ring systems or heterocyclic ring systems containing 5 to 10 ring atoms of which 1, 2 or 3 can be identical or different ring heteroatoms selected from nitrogen, oxygen and sulfur, where the resulting R4(R5)C group is unsubstituted or substituted by 1 or more identical or different substituents R10; R6 is selected from hydrogen, hydroxy, (C1-C8)-alkoxy, (C6-C14)-aryl-(C1-C4)-alkoxy-; A is halogen; X is sulphur or oxygen; m is 0-4 and n is 0-3. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of thromboembolic diseases and restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them. |
| priorityDate | 2000-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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