| abstract |
A pharmaceutical composition comprising an effective amount of a diuretic agent and an effective amount of a vasopressin antagonist of formula (I), wherein R and R5 are H or lower alkyl; R1, R2 and R3 are H, halo, lower alkyl, lower alkoxy, amino, alkylamino or dialkylamino; and R4 is H or optionally substituted phenyl and pharmaceutically acceptable salts thereof. This pharmaceutical composition is useful in the treatment of edematous conditions in an animal. |