| abstract |
An isolated oligopeptide of between about 5 and about 10 amino acid residues in length having hair growth promoting activity comprising the amino acid sequence selected from: X1-X2-X3-X4-X5-X6-X7, X1-X2-X3-X4-X6-X5-X7, X1-X2-X3-X-X6-X4-X5-X7 or X1-X2-X6-X3-X4-X5-X7; wherein X1 is Ser, Ala, Tyr, Pro, Phe, Val, Gly, Leu, Ile or Met or is deleted from the oligopeptide; X2 is Ile, Gly, Asn, Thr, Val, Ser, Phe, Leu, Ala, Pro, Cys or Met or is deleted from the oligopeptide; X3 is Glu, Lys, Gln, Arg, Ala, Val, Trp, Cys or Asp; X4 is Gln, Pro, Glu, Thr, Arg, Ser, His, Cys or Lys; X5 is Ser, trp, Phe, Thr, Cys, Tyr, Pro, Ala, Gly, Val, Leu, Ile or Met X6 is Cys , a reactive substance-bound Cys or a reactive substance-bound Lys; X6 is Asp, Glu, His, Ser, Ala, Gly, Asn, Tyr, Arg or Leu or is deleted from the oligopeptide; with the proviso that the oligopeptide is not identical to SEQ ID NO:1, SEQ ID NO:2, SER-Glu-Gln-Ser-Cys-Asp or Ser-Ile-Glu-Gln-Ser-Cys. A composition comprising the oligopeptide can be used in the manufacture of a medicament for promoting hair growth. |