http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-521773-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_313a5f9e3decaee61deaaaa1c737390c |
| filingDate | 1998-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b7d30cf57e5fdeb9fcf25c15f7cf39a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d9ff695c60b4dafd65585ab7ea9a412 |
| publicationDate | 2006-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-521773-A |
| titleOfInvention | Use of formulations for hydrophobic pharmaceutical agents in treatment or prevention of cell proliferative disorders |
| abstract | A use, in the manufacture of a medicament for preventing or treating a cell proliferative disorder in a human patient in need of treatment, of a diluted parenteral formulation comprising one or more hydrophobic pharmaceutical agents, wherein said agents are independently selected from the group consisting of a quinazolin-, a nitrothiazole- and an indolinone-based compound; one or more polyoxyhydrocarbyl compounds; and one or more pharmaceutically acceptable surfactants; wherein said indolinone-based compound is an indolinone-based compound of formula (VI) at a concentration of about 0.1 to about 100 mg/nil; wherein R1, R2, R3, R4 are selected from the group consisting of hydrogen, trihalomethyl, hydroxyl, thioether, cyano, alkoxy, aikyl, amino, bromo, fluoro, chioro, iodo, mercapto, thio, cyanoamido, aikylthio, aryl, heteroaryl, carboxyl, ester, oxo, alkoxycarbonyl, aikenyl, alkoxy, nitro, alkoxyl, and amido moieties; and R5 is an optionally substituted aryl or heteroaryl cyclic moiety; wherein at least one or said surfactants for the indolinone-based compound is PEG-400 at a concentration of about 0.01 to about 10 g/ml and at least one of said polyoxyhydrocarbyl compounds for the indolinone-based compound is ethoxylated castor oil at a concentration of about 0.01 to 10 g/ml. |
| priorityDate | 1997-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 407.