| abstract |
Disclosed are compounds of formula 1, wherein: R1 is alkyl or cycloalkyl, which are optionally substituted with optionally substituted phenyl, alkyloxy, S-alkyl or N(alkyl)2, R2, R3, R4 and R5 are independently H, halo, nitro, alkyl, alkyloxy; or aryl-alkyloxy, aryloxy, aryl, cycloalkyl or O-cycloalkyl, which are optionally substituted with halo, CF3, alkyloxy or alkyl; or 2-oxopyrrolidin-1-yl, 2,5-dimethylpyrrol-1-yl or NR6-A-R7, with the proviso that R2, R3, R4 and R5 are not simultaneously H, and at least one of R2, R3, R4 or R5 is 2-oxopyrrolidin-1-yl, 2,5-dimethylpyrrol-1-yl or NR6-A-R7, and the remaining substituents are defined herein. The compounds are used in the manufacture of pharmaceuticals for use in inhibiting hormone-sensitive lipase. |