| abstract |
Compounds of formula (1), their pharmaceutical compositions, or pharmaceutically acceptable salts thereof, that are useful in the treatment of, inter alia, type 2 diabetes are disclosed, wherein R1 is H or CN; X1 is S, O, SO2 or CH2; X2 is O, S or CH2; X3 is NR5 or a carbonyl or thiocarbonyl group; and R4 is R6R7N, R8(CH2)qOC(=O), R8(CH2)qOC(=S), R6R7NC(=O), R6R7NC(=S), R8(CH2)qC(=O), R8(CH2)qC(=S) or R8(CH2)qSO2, m is 1-3 and n is 0-4, all other variables are as defined in the specification. |