| abstract |
A method for producing a non-human mammal which has an altered tendency to produce progeny of a particular sex, comprising introducing a nucleic acid construct into at least one sex chromosome of the germ line of said mammal, wherein said nucleic acid construct encodes a transgene which is expressed post-meiotically in developing spermatids, and wherein expression of said transgene alters the fertility of sperm resulting from said developing spermatids, such that said mammal has an altered tendency to produce progeny of a particular sex. |