http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-518964-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab6f907da23c9c792d65fb63fb6893a8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5152 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-14 |
| filingDate | 2000-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c8f0988013bff17b9bde92d9cd0d9f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efcdebf59255d72e34786ceae6680bb7 |
| publicationDate | 2003-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-518964-A |
| titleOfInvention | Immunotherapy to enhance the response of T cells to tumor cells by inhibiting expression of the Notch ligand |
| abstract | Described is the use of a T cell having enhanced reactivity towards a tumor cell for the preparation of a medicament for the therapeutic and/or prophylactic treatment of a malignancy. The T cell is prepared by exposing a T cell obtained from a patient to an agent which is capable of reducing or preventing expression or interaction of an endogenous Notch or Notch ligand in the cell. The T cell comprises a T cell receptor specific for a tumour antigen expressed by the tumour cell. The T cell can also be prepared by exposing an antigen presenting cell (APC) obtained from a tumour to an agent which is capable of reducing or preventing expression or interaction of an endogenous Notch or Notch ligand in the T cell when the T cell is contacted with the APC or by exposing a tumour cell obtained from a patient with to an agent which is capable of reducing or preventing expression or interaction of an endogenous Notch or Notch ligand in the T cell when the T cell is contacted with the tumour cell. Also described is an anti-tumor vaccine comprising a tumour antigen and an agent which is capable of reducing or preventing interaction, expressing or processing of Notch or a Notch ligand. |
| priorityDate | 1999-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 757.