| abstract |
A homogeneous crystalline polymorph of the hydrochloride salt of N- (3-ethynylphenyl)-6,7-bis(2 methoxyethoxy)-4-quinazolinamine designated the B polymorph that exhibits an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2-theta at approximately 6.26, 12.48, 13.39, 16.96, 20.20, 21.10, 22.98, 24.46, 25.14 and 26. 91. The compound is used to treat abnormal cell growth such as cancer and atherosclerosis. N- (3-ethynylphenyl)-6,7-bis(2 methoxyethoxy)-4-quinazolinamine in anhydrous from or hydrate form is used in the manufacture of a medicament to treat non small cell lung cancer, pediatric malignancies, cervical and other tumours caused or promoted by human papilloma virus, endometrial cancer, Barrett's esophagus (pre malignant syndrome) or neoplastic cutaneous diseases. |