| abstract |
A pleuromutilin derivative of the formula I or a pharmaceutically acceptable salt thereof is used in the manufacture of a medicament for the transdermal treatment of bacterial infections in animals. In formula (I): R1 is ethyl or vinyl; Y is COOH, -CH2-R2 or a group of formula (2); R2 is H, halogen, OH, NH2, SCN, N3, COOH, C(S)S-alkyl, optionally hydroxy substituted -S-pyridyl, optionally substituted alkylthio, -O-SO2-(4-methylphenyl), -S-(CH2)m- X, -(CH2-Z)r-(CH2)s-Q, -S-C(CH3)2-CH2-NH-C(O)-Q or -S- C(CH3)2-CH2-NH-C(O)-CH(NH2)-CH(CH3)2; X, Q and Z are as defined in the specification; m is 0 to 5; r is 0 or 1 and s is 2 to 5. |